Pregnancy Increases Risk for Symptomatic Kidney Stone
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Pregnancy increases the risk for first-time symptomatic kidney stone formation which peaks close to the time of delivery but can persist even a year later, a population-based, case-controlled study suggests.

There are several well-known anatomical and physiological changes during pregnancy that could contribute to kidney stone formation, but evidence that they increase the risk of kidney stones during pregnancy is lacking. Researchers determined whether there was an increased risk of a first-time symptomatic kidney stone during and after pregnancy.

A population-based matched case-control study included 945 female first-time symptomatic kidney stone formers aged 15-45 years and 1,890 age-matched female controls in Olmsted County, MN, from 1984-2012. The index date was the date of onset of a symptomatic kidney stone for both the case and her matched controls.

--Compared with nonpregnant women, the odds of a symptomatic kidney stone forming in women was similar in the first trimester, began to increase during the second trimester, further increased during the third trimester, peaked at 0 to 3 months after delivery, and returned to baseline by 1 year after delivery.

--These associations persisted after adjustment for age and race or for diabetes mellitus, hypertension, and obesity. These results did not significantly differ by age, race, time period, or the number of prior pregnancies.

--Having a prior pregnancy was also associated with a first-time symptomatic kidney stone.

In particular, pregnancy increases the risk of a first-time symptomatic kidney stone. This risk peaks close to delivery and then improves by 1 year after delivery, though a modest risk of a kidney stone still exists beyond 1 year after delivery.

Source: https://doi.org/10.1053/j.ajkd.2021.01.008
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