Pregnancy complicated with hepatitis B virus infection and p
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This BMC Pregnancy and Childbirth study suggests that hepatitis B virus infection is an independent risk factor for early preterm birth (PTB).

Researchers retrospectively analyzed HBV-infected and non-infected pregnant women attending antenatal care. Participants were divided into HBV infection (n=1302) and control (n=12,813) groups.

They compared baseline data, pregnancy, and perinatal complications, and preterm delivery outcomes between groups. Performed multiple logistics regression analyses to adjust for confounding factors. Finally, we compared early PTB outcomes between different HBV DNA level groups.

- The incidence of preterm birth (gestation less than 37 weeks) was similar between the groups, early preterm birth (gestation less than 34 weeks) was significantly more among the HBV infection group than among the controls.

- After adjusting for confounding factors through logistics regression, HBV infection was found to be an independent early PTB risk factor gestation.

- The incidence of early PTB in < 500 groups, 500 ~ 2.0 × 10e5 group, and>2.0× 10e5 group was not statistically significant.

Conclusively, HBV infection is an independent risk factor for early PTB, and the risk did not seem to be influenced by the levels of HBV DNA.

Source: https://doi.org/10.1186/s12884-021-03978-0
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