Pregnancy outcomes in women with type 2 diabetes treated wit
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Metformin use in pregnancy is controversial because metformin crosses the placenta and the safety on the fetus has not been well-established. This retrospective study aimed to compare pregnancy outcomes in women with preexisting type 2 diabetes receiving metformin or standard insulin treatment.

A total of 1166 pregnancies were identified in the insulin group, the switching group and the metformin group. The insulin group and the switching group had similar pregnancy outcomes for both the mother and fetus, including the risk of primary cesarean section, pregnancy-related hypertension, preeclampsia, preterm birth, very preterm birth, low birth weight, high birth weight, large for gestational age, and congenital malformations. The metformin group had a lower risk of primary cesarean section and congenital malformations and similar risk for the other outcomes as compared with the insulin group.

In conclusion, data reveal that metformin treatment for women with type 2 diabetes in pregnancy is not associated with an increased risk of adverse pregnancy outcomes compared with standard insulin therapy.

Source: https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-03207-0
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