Pregnancy with mitochondrial disease complicated by threaten
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Introduction
Mitochondrial diseases are disorders associated with the dysfunction of the mitochondria, which cause a variety of systemic disorders. We experienced a case of a pregnancy complicated with mitochondrial disease. The pregnancy was complicated with threatened premature labor, preeclampsia, and magnesium intolerance. However, her diabetes mellitus had been stable during the course of pregnancy despite administration of ?2-stimulant.

Case
The patient was a 33-year-old, gravida 3, primiparous, pregnant woman. She had a history of 3 spontaneous abortions. The patient had type I diabetes mellitus, diagnosed at 18 years of age, and had been receiving insulin injections since that time. At 24 years old, she underwent genetic testing at another facility, which revealed a point mutation of mitochondrial DNA in m3243. Her hearing disability was apparent—she used a hearing aid—and she was diagnosed with maternal-inherited diabetes with deafness. Because of recurrent miscarriage, she had visited an infertility clinic. Her hemoglobin A1c level was 5.6% before pregnancy. However, slight decease in the activity of coagulation factor XII was observed and low-dose aspirin was prescribed. She had conceived naturally but, because of her pre-pregnancy medical history, she was referred to our institution at 9 weeks of gestation.....

https://www.jstage.jst.go.jp/article/jsshp/4/1/4_HRP2015-015/_html
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