Prenatal Antidepressant use and the Implication of Hypertens
This study shows no association between antidepressant use and the development of hypertensive disorders except at high cumulative doses. The study was published in the American Journal of Obstetrics & Gynecology.

This study aimed to investigate the association between prenatal antidepressant use and the risk of hypertensive disorders of pregnancy, as well as the potential effect of a higher cumulative antidepressant dose.

Pregnant women aged 18 to 49 years with depression were enrolled as the study population. Prenatal antidepressant use was defined as at least one dispensing record of an antidepressant between the conception date and 20 weeks of gestation. Antidepressant users were further divided into groups by the cumulative defined daily dose (cDDD) based on whether they took the defined daily dose for ≤10 weeks (low cumulative dose group: ≤70 cDDD) versus > 10 weeks (high cumulative dose group: >70 cDDD). The primary outcome was hypertensive disorders of pregnancy defined as the diagnosis of either gestational hypertension or preeclampsia from 20 weeks of gestation to delivery.

A total of 5,664 pregnant women with depression were included in the study.

--Prenatal antidepressant use was not associated with an increased risk of hypertensive disorders of pregnancy.

--However, among antidepressant users, the risk of hypertensive disorders of pregnancy was higher in women with higher cDDD than women with lower cDDD.

In particular, no association was found between antidepressant use and the development of hypertensive disorders during pregnancy. However, women taking higher cumulative doses of antidepressants were at greater risk. More frequent or regular monitoring of blood pressure may be warranted in women on high cumulative doses of antidepressants.

Source: https://doi.org/10.1016/j.ajog.2021.06.003
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