Prenatal urinary concentrations of phenols and risk of prete
The study finds links between mid-to-late pregnancy bisphenol A (BPA) and early pregnancy paraben concentrations with preterm birth among those with female infants.

The study explored windows of vulnerability to prenatal urinary phenol concentrations and preterm birth.

A total of 386 mothers who sought fertility treatment and gave birth to a singleton were included.

- Compared with women with non-preterm births, urinary bisphenol A (BPA) concentrations were higher across gestation among women with preterm births, particularly during mid-to-late pregnancy and among those with female infants.

- Second trimester BPA concentrations were associated with preterm birth, which was primarily driven by female and not male infants.

- First trimester paraben concentrations were also associated with preterm birth and similarly the association was only observed for female and not male infants.

- First trimester urinary bisphenol S concentrations showed a suggested risk of preterm birth, although the small case numbers precluded sex-specific examination.

In particular, they found preliminary evidence of associations between mid-to-late pregnancy BPA and early pregnancy paraben concentrations with preterm birth among those with female infants only. Preterm birth risk may be compound, sex, and window specific.

Fertility and Sterility
Source: https://doi.org/10.1016/j.fertnstert.2021.03.053
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