Preoperative administration of LMW Heparin safe in lung canc
Preoperative administration of low molecular weight heparin demonstrates safety and feasibility for lung cancer patients intended to receive minimally invasive surgery, states a recent study published in the BMC Surgery.

Current guidelines recommend thromboprophylaxis for lung patients at high risk of thrombosis, while a consensus about specific administration time is not reached. This study was designed to investigate the safety profile of preoperative administration of low-molecular-weight-heparin (LMWH) for lung cancer patients.

Patients prepared to undergo lung cancer surgery were randomly divided into the preoperative LMWH-administration group (PRL) for 4000 IU per day and the postoperative LMWH-administration group (POL) with the same dosage, all the patients received thromboprophylaxis until discharge. Baseline characteristics including demographics and preoperative coagulation parameters were analyzed, while the endpoints included postoperative coagulation parameters, postoperative drainage data, hematologic data, intraoperative bleeding volume, and reoperation rate.

A total of 246 patients were collected in this RCT, 34 patients were excluded according to exclusion criterion, 101 patients were assigned to the PRL group and 111 patients belonged to the POL group for analysis finally.

--The baseline characteristic and preoperative coagulation parameters were all comparable except the PRL group cost more operation time and preoperative administration duration was significantly longer.

--The endpoints including postoperative day 1 coagulation parameters, mean and total drainage volume, drainage duration, intraoperative bleeding volume, and reoperation rate were all similar between the two groups.

--Moreover, coagulation parameters for postoperative day 3 between the two groups demonstrated no difference.

Conclusively, preoperative administration of low-molecular-weight-heparin demonstrated safety and feasibility for lung cancer patients intended to receive minimally invasive surgery.

Source: https://doi.org/10.1186/s12893-021-01244-w
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