Preoperative leukocytosis correlates with unfavorable pathol
The study meta-analytically examines the frequency and prognostic impact of preoperative leukocytosis in endometrial carcinoma (EC).

Five major databases were searched. Studies that evaluated the frequency of preoperative leukocytosis or its correlation with pathological and survival outcomes in EC patients were included. Data were pooled as mean differences (MD), odds ratios (OR), or hazard ratios (HR) with 95% confidence intervals. Nine retrospective studies, with a low risk of bias, were included.

- The pooled prevalence of preoperative leukocytosis was 11.2%. There was a significant correlation between preoperative leukocytosis and FIGO stage III-IV, ?50% myometrial invasion, lymph node involvement, cervical involvement, adnexal involvement, and tumor size.

- However, preoperative leukocytosis did not significantly correlate with tumor grade II-III, non-endometrioid histology, peritoneal cytology, and lymphovascular space involvement.

- Additionally, preoperative leukocytosis correlated with higher rates of death, tumor recurrence, and worse overall survival at univariate and multivariate analyses.

- As for disease-free survival, preoperative leukocytosis emerged as an independent prognostic factor on univariate but not multivariate analyses.

In conclusion, preoperative leukocytosis is common and correlates with poor pathological and survival outcomes in EC patients.

European Journal of Obstetrics & Gynecology and Reproductive Biology