Preoperative vitamin D deficiency is associated with increas
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Postoperative hypocalcemia is a common complication of total or completion thyroidectomy. The prevalence of this condition was reported to be 10% to 50% and 0.5% to 4.4% for transient and permanent hypocalcemia, respectively.

In this study, researchers employ a multi-institutional, de-identified electronic health records database to address this issue. Investigators hypothesize that total thyroidectomy patients with preoperative vitamin D deficiency (VDD) will be at an increased associated risk of postoperative hypocalcemia and hospitalization.

Using Cerner Health Facts, researchers identified 2447 patients who underwent total or subtotal thyroidectomy and who had a documented 25-hydroxyvitamin D concentration obtained within 12?months of the surgery date. Data from 984 patients who underwent total thyroidectomy were analyzed. Analysis of variance models estimated the effect of VDD on postoperative numerical variables. Multiple logistic regression estimated the risk of postoperative hypocalcemia and hospital stay, adjusting for any imbalanced demographic variables and operative characteristics.

--On average, postoperative total calcium concentrations in the VDD group were lower by 0.3?mg/dL compared with that of the non-VDD group.

--The risk of postoperative hypocalcemia was 2.2 times higher in the VDD group compared with the non-VDD group.

--Although the length of hospital stay after thyroidectomy was longer in the VDD group compared with the non-VDD group, VDD is not an independent risk factor for prolonged hospitalization following thyroidectomy.


In particular, VDD is associated with a higher risk of hypocalcemia following total thyroidectomy. Prethyroidectomy operative screening for VDD should be considered.

Journal of Investigative Medicine
Source: http://dx.doi.org/10.1136/jim-2020-001644
Like
Comment
Share