Presence of thinner Retinal nerve fibre layer in young adult
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In foetal alcohol spectrum disorders, ophthalmological anomalies such as ptosis, strabismus, refractive errors, and optic nerve hypoplasia have been identified (FASD). The aim of this study was to see if there were any differences in retinal thickness, retinal nerve fibre layer (RNFL), and optic disc region (ODA) between people with FASD and healthy people.

Best-corrected visual acuity (BCVA) in terms of logarithm of the minimum angle of resolution (logMAR), refraction, and fundus variables measured by optical coherence tomography were obtained from 26 young adults with FASD (12 women, median age 23 years) and 27 controls (18 women, median age 25 years).

Results:
--The total thickness of the peripapillary RNFL was significantly lower in the FASD group than in controls; median (range) in the right/left eye was 96.5/96 microm in the FASD group and 105/103 microm among controls.

--Macular RNFL and retinal thickness measurements from the FASD group were also lower in most of the 9 ETDRS areas, except for the central parts.

--Median (range) BCVA in the best eye was 0.00 logMAR in the FASD group and 0.00 logMAR in controls. No significant differences between the groups were found regarding ODA or refraction.

Finally, when this group of young adults with FASD was compared to healthy controls, significant variations in peripapillary and macular RNFL, retinal thickness, and BCVA were discovered. The size of the optic disk, on the other hand, did not vary.

Source: https://bjo.bmj.com/content/105/6/850?rss=1
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