Presentation and survival of gastro-entero-pancreatic neuroe
Highlights
• The youngest 5% of patients with neuroendocrine tumors make up a minority of patients.

• The most common sites of neuroendocrine tumors in young patients are the appendix, the pancreas, and the small bowel.

• Young patients tend to present with the more early-stage disease with well-differentiated histology.

• On multivariate analysis, young age, well-differentiated histology, early-stage, and surgical intervention were associated with a lower risk of mortality.

A minority of patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) are diagnosed at younger age. This population-based study explores the broad clinical and pathologic features of the youngest 5% of adult patients with GEP-NETs. The researcher identified 31,983 patients with a diagnosis of a GEP-NET and only 5% of patients were under the age of 35. Young patients were found to have greater proportions of localized, well-differentiated disease. On multivariate analysis, young age, well-differentiated histology, early-stage, and surgical intervention were associated with lower risk of mortality. Young patients with GEP-NETs tend to have an earlier stage of presentation and well-differentiated tumors, which may be most amenable to surgical intervention.

Source:https://www.sciencedirect.com/science/article/abs/pii/S0002961021005134
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