Previous infection with 'common cold' coronavirus may lessen
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Being previously infected with coronaviruses that cause the 'common cold' may decrease the severity of COVID-19, according to the study, published in the Journal of Clinical Investigation.

It also demonstrates that the immunity built up from previous non-SARS-CoV-2 coronavirus infections does not prevent individuals from getting COVID-19.

There are many other types of coronaviruses that are endemic in humans and can cause the "common cold" and pneumonia.

These coronaviruses share some genetic sequences with SARS-CoV-2, and the immune responses from these coronaviruses can cross-react against SARS-CoV-2.

The study looked at electronic medical record data from individuals who had a respiratory panel test (CRP-PCR) result between May 18, 2015 and March 11, 2020. Also examined data from individuals who were tested for SARS-CoV-2 between March 12, 2020 and June 12, 2020.

CRP-PCR detects diverse respiratory pathogens including the endemic "common cold" coronaviruses.

After adjusting for age, gender, body mass index, and diabetes mellitus diagnosis, COVID-19 hospitalised patients who had a previous positive CRP-PCR test result for a coronavirus had significantly lower odds of being admitted to the intensive care unit (ICU).

They also had lower trending odds of requiring mechanical ventilation during COVID, the researchers said.

The probability of survival was also significantly higher in COVID-19 hospitalised patients with a previous positive test result for a common cold coronoavirus.

However, a previous positive test result for a coronavirus did not prevent someone from getting infected with SARS-CoV-2.

Source: https://www.jci.org/articles/view/143380
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