Primary Amyloidosis of the Bladder Mimicking Probable Malign
Amyloidosis is a disease process characterized by extracellular deposition of amyloid protein within tissues, which can eventually cause symptomatic organ dysfunction. It can occur in a systemic or localized fashion, and is further classified as either primary or secondary amyloidosis depending on the underlying disease process. The symptoms commonly reported with bladder amyloidosis are painless gross or microscopic hematuria, dysuria, and irritative voiding symptoms.

The definitive diagnosis of amyloidosis is made by histopathology, which reveals the presence of amyloid fibrils on Congo-red immunostaining and apple-green birefringence upon polarization. Treatment of this condition is typically conservative with transurethral resection. Follow up cystoscopy procedures can also be done to evaluate for recurrence.

Source: Urology case report

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