Primary hepatoid Adenocarcinoma of the orbit
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Hepatoid adenocarcinoma (HAC) is a rare extrahepatic malignant tumor that is characterized by a histologic resemblance to hepatocellular carcinoma (HCC). HAC is most commonly reported in the stomach and has been identified in multiple abdominal-pelvic organs, the lungs, and other sites. Typically, patients with HAC present with elevated serum alpha-fetoprotein (AFP), and with tumor immunohistochemistry positivity for AFP, however both of these features are variable in reports. Although HAC of the skull base has recently been reported, to our knowledge, it has not yet been reported as a primary tumor of the orbit. An adult patient was referred for evaluation of an orbital mass. Histopathology of the orbital biopsy indicated a carcinoma with hepatoid features. Laboratory studies revealed normal liver function tests, elevated serum alpha-fetoprotein, and whole-body positron emission tomography/computed tomography scan showed no evidence of liver involvement or an alternative primary origin.

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