Primary non-Hodgkin's lymphoma of the skull with extra and i
Abstract
Primary non-Hodgkin's lymphoma (NHL) of the cranium with extra- and intracranial extension without systemic or skeletal manifestation in a non-immunocompromised patient is extremely rare. These lesions are most of the time misdiagnosed because they mimic other conditions like meningioma. Here, we report a case presented with huge bulky scalp mass which on magnetic resonance imaging (MRI) brain showed involvement of scalp, cranial vault, meninges, and the brain parenchyma, mimicking a meningioma. After gross total resection, biopsy and CD marker study revealed primary non-Hodgkin's diffuse large B-cell lymphoma (DLBCL). Malignant NHL should be considered in differential diagnosis of bulky scalp mass lesion.

Case Report
A 40-year-old lady presented with progressively increasing unsightly bulky huge scalp mass over bilateral frontoparietal region of 1 year duration. She had occasionally mild headache and no other signs and symptoms. There was no history of trauma, fever, or any other illness in the past. On examination, she was conscious and without any neurological deficit. There was slight tender huge bulky mass over bilateral frontoparietal region, with a firm, ill-defined, and bosselated surface. There was no local rise of temperature, and skin over it was healthy except left forehead region where there was superficially excoriation [Figure 1]. Her blood investigations were normal. Investigations for HIV infection were negative......

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974974/?report=reader
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