Probabililty of Anterior segment ischemia after laser for re
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A Study was conducted to assess the risk of vision-threatening anterior segment ischemia (ASI) among retinopathy of prematurity (ROP) patients treated with anti-VEGF followed by laser photocoagulation.

The medical records of all infants treated for threshold ROP with laser photocoagulation with and without prior anti-VEGF injections were retrospectively reviewed for the prevalence of vision-threatening ASI.

Results:
--A total of 241 eyes of 122 infants were included. Mean gestational age was 25.1 weeks (range, 22.9-28.7); mean birth weight was 687.6 g (range, 360–1310 g).

--Of the 54 eyes (27 patients) treated with anti-VEGF prior to laser, 4 developed ASI (including corneal edema, cataracts, and choroidal effusion) compared with 2 of the 187 eyes (95 patients) treated with laser therapy alone.

--Infants receiving both anti-VEGF and laser had a younger gestational age at birth (24.5 vs 25.3 weeks) and lower birth weight (591.4 g vs 715.0 g) than those who received laser alone.

--In multivariate analysis, early gestational age at birth was associated with development of ASI; the association with anti-VEGF treatment fell short of statistical significance.

Finally, when comparing infants treated with intravitreal anti-VEGF accompanied by laser to those treated with laser alone, the incidence of vision-threatening ASI was higher.

Source: https://www.jaapos.org/article/S1091-8531(21)00111-7/fulltext?rss=yes
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