Probiotics: elixir or empty promise?
The current issue of Lancet Gastroenterology & Hepatology carries the present editorial evaluating the beneficial role of probiotics if any.

The gut microbiota has been implicated in diseases ranging from obesity to Parkinson's disease and depression. Little wonder then that commercial probiotics have gained widespread popularity and are now estimated to command a US$37 billion market worldwide.

But with research into the microbiome still in its infancy, increasing evidence suggests that both commercial and clinical use of probiotics is outpacing the science.

Evidence from clinical trials is mixed and often of low quality, but findings from meta-analyses suggest that probiotics can provide benefits in the treatment of some conditions, such as infectious and antibiotic-associated diarrhoea. As such, taking probiotics after antibiotic treatment is an increasingly common practice.

However, two studies recently reported in Cell question whether taking highly concentrated supplements of so-called good bacteria aids the recovery of normal gut flora.

A recent research investigated the recovery of the gut microbiota after antibiotic treatment and found that probiotics might perturb rather than aid this process. The probiotics rapidly colonised the gut but prevented the normal microbiota from repopulating for up to 5 months. While likely to be considerably less appealing, the group who received autologous faecal microbiota transplantation recovered their microbiota the quickest, with the composition of the microbiota returning to normal within days.

A separate research demonstrated that colonisation occurred in highly individualised patterns, with some people's gastrointestinal tracts rejecting probiotics and others allowing colonisation by the probiotic strain, meaning that many individuals taking probiotic supplements are simply wasting their money.

"While the logic behind probiotics might seem sound, it is clear that we have a long way to go before understanding the complexity of the microbiota and the effects—both good and bad—that probiotics might have. All individuals have a unique gut microbiome, and the effects of different bacteria on different people are likely to be highly variable; as such, probiotic use might even need to be personalised for optimal benefits", the article concludes.

Read more here: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(18)30415-1/fulltext
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Dr. N●●●●a G●●●a
Dr. N●●●●a G●●●a Obstetrics and Gynaecology
With a wide range in types of pre and probiotics there effect also varies from individual to individual, internal GI melieu is not the same in different individuals and in different ailments.
Jan 10, 2019Like3
Dr. N●●●●a G●●●a
Dr. N●●●●a G●●●a Obstetrics and Gynaecology
All reaserches are based on some assumption from the past references, or current obeservation,as a passing remark it is not wrong, it may be a stimulus to researchers, all researches are based on thought provoking stimulus, be it Archemedis or steam engine,ancient history is always alien and like a story narration, we need to give such remarks little importance and not make them an issue, guidlines is a good idea,few seconds can be devoted as a mark of respect to our forefathers as in any espaciality.... Read more
Jan 10, 2019Like3