Progestogen effective for Rx threatened miscarriage: Cochrai
Spontaneous miscarriage occurs in about 15% to 20% of pregnancies. Threatened miscarriage occurs when a mother might be losing her baby at less than 20 weeks' gestation. The symptoms of threatened miscarriage are vaginal bleeding, with or without abdominal pain, while the cervix of the womb is closed and the baby inside the womb is alive. Medications that mimic the action of progesterone are known as progestogens.

In the present review, the authors investigated if progestogens are effective and safe in the treatment of threatened miscarriage, which may increase the women's chances of having a successful pregnancy and a live birth.

The results of this Cochrane Review suggest that progestogens are probably effective in the treatment of threatened miscarriage but may have little or no effect in the rate of preterm birth.

The evidence on congenital abnormalities is uncertain, because the quality of the evidence for this outcome was based on only two small trials with very few events and was found to be of very low quality.

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