Progression of Partial Posterior Vitreous Detachment Over Ti
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Researchers investigated inter-individual differences in the rate of change of posterior vitreous detachment (PVD) stage and vitreomacular adhesion area (VMAA). Cross-sectional studies demonstrated increasing posterior vitreous detachment stage and decreasing vitreomacular adhesion area with age, but population-level means may mask inter-individual variation in the rate of change.

Researchers retrospectively evaluated posterior vitreous detachment stage and vitreomacular adhesion area in asymptomatic eyes of subjects who underwent repeated optical coherence tomography screening for high-risk medication use or isolated retinal disease in the fellow eye. A Turnbull estimator modeled changes in the posterior vitreous detachment stage, and linear mixed models evaluated vitreomacular adhesion area change.

Researchers evaluated 101 eyes of 101 subjects. 76 eyes remained at the same stage. 23 eyes progressed to a higher stage. Modeling of longitudinal data predicts that at age 30, the time to convert to stage 4 is 26 years; at age 40, it is 16 years; at age 50, it is 9 years; and at age 60, it is 8 years. In 37 eyes with stage 1 partial posterior vitreous detachment, the vitreomacular adhesion area decreased at a similar rate. The average population-level decline in vitreomacular adhesion area was 0.13 mm2/year.

Individuals vary in the age at which they progress to complete posterior vitreous detachment. In early partial posterior vitreous detachment, the vitreomacular adhesion area decreases at a similar rate across individuals.

Source:https://journals.lww.com/retinajournal/Abstract/9000/Progression_of_Partial_Posterior_Vitreous.95654.aspx
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