Progressive, subretinal fibrosis mimicking retinal necrosis
Published in the Indian Journal of Ophthalmology, the authors report a rare finding of progressive subretinal fibrosis mimicking retinal necrosis in 2 cases of sympathetic ophthalmia.

Histopathology of the inciting eye and vitreous biopsy of the sympathizing eye ruled out infections and masquerades. Progression of inflammation and rapid deterioration of vision inspite of maximum immunosuppression are key findings in this variant of sympathetic ophthalmia.

Sympathetic ophthalmia is a rare, bilateral, diffuse granulomatous intraocular inflammation that occurs after a surgery or penetrating trauma to one eye. Most commonly described ocular manifestations include granulomatous panuveitis, exudative retinal detachment, papillitis, presence of Dalen Fuchs nodules and depigmentary alterations in the fundus.

High-dose corticosteroids and immunosuppressants initiated at an early stage is necessary for a good visual prognosis. Very rarely, they present with severe subretinal fibrosis resulting in poor visual prognosis.

Read in detail about the cases here: