Prolonged transitional neonatal hypoglycaemia: Characterisat
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A case-control study was performed to characterise infants with “prolonged transitional hypoglycaemia”.

Cases that were born with more than 36 weeks gestation had more than 1 hypoglycaemic episode in less than 72h and more than 72h. They received ongoing treatment for hypoglycaemia in more than 72h and were without congenital disorders or acute illness.
Cases were compared to controls born more than 36 weeks with brief transitional hypoglycaemia, resolving in less than 72hr.

Results:
471 infants were screened in which 39 met case definition:
71.8% were male, 61.5% were small-for-gestational-age (SGA), and most were admitted in less than 6h.
Compared to controls (N=75), key risk factors for prolonged transitional hypoglycaemia were SGA (OR=6.4), severe/recurrent hypoglycaemia less than 24h (OR=16.7), intravenous glucose bolus less than 24h (OR=26.6) and maximum glucose delivery rate less than 48h of more than 8mg/kg/min (OR=25.5).

It was concluded that infants with prolonged transitional hypoglycaemia are predominantly male, small-for-gestational-age and have early severe/recurrent hypoglycaemia requiring glucose boluses and high glucose delivery rates in the first 24–48h.

Source: https://www.nature.com/articles/s41372-020-00891-w
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