Prophylactic Topical Tranexamic Acid versus Placebo in Surgi
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Topical tranexamic acid (TXA) decreases the incidence of blood transfusion and mortality in adults undergoing surgery states a recent study published by the Annals of Surgery.

Perioperative bleeding remains a major concern to all clinicians caring for perioperative patients. The primary aim of this review was to assess the effect of topical TXA on the incidence of blood transfusion and mortality in adults undergoing surgery.

EMBASE, MEDLINE, CENTRAL, and ISI Web of Science were systematically searched. Seventy-one trials (7539 participants: orthopedics 5450 vs nonorthopedics 1909) were included for quantitative meta-analysis.

The findings were;
--In comparison to the placebo, topical TXA significantly reduced intraoperative blood loss, total blood loss, and incidence of blood transfusion.

--Patients who received topical TXA were associated with a shorter length of hospital stay.

--No adverse events associated with the use of topical TXA were observed, namely mortality, pulmonary embolism, deep vein thrombosis, myocardial infarction, and stroke.

In the meta-analysis of 71 trials, topical TXA reduced the incidence of blood transfusion without any notable adverse events associated with TXA in adults undergoing surgery.

Source: https://journals.lww.com/annalsofsurgery/Abstract/2021/04000/Prophylactic_Topical_Tranexamic_Acid_Versus.10.aspx
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