Prostatic Enlargement Linked to Obesity
Increasing abdominal obesity and serum leptin levels are associated with increased prostate volume, according to a new study.

The investigators also stated that insulin may influence transcription of genes involved in sex hormone metabolism. These genes alter the androgen to estrogen ratio and circulating level of sex hormone-binding globulin, the researchers explained. “Such alterations in the testosterone to estrogen ratio in prostate tissue may contribute to BPH development.”