Proteomic analysis of elevated intraocular pressure with ret
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The majority of eyes with rhegmatogenous retinal detachment present with relative hypotony, while elevated intra-ocular pressure (IOP) is less frequent. In a large retinal detachment case series, glaucoma was present in 9.5% of patients, ocular hypertension in 6.5%, and an estimated 2.1% of patients with an elevated IOP due to Schwartz-Matsuo syndrome. The elevated IOP in Schwartz-Matsuo syndrome occurs during chronic retinal detachment when the liberation of photoreceptor outer segments blocks the trabecular meshwork, as shown by electron microscopy. To our knowledge, there are no proteomic studies on patients with elevated IOP following retinal detachment, which could easily confirm the presence of photoreceptor outer segment proteins in the anterior chamber. Here we present a case of elevated IOP in a patient with chronic retinal detachment who was clinically diagnosed with Schwartz-Matsuo syndrome, but molecular analysis of the aqueous humor suggested a different etiology.

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