Psychiatric Disorders and Suicidal Behavior was less in pati
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A Study was conducted to investigate whether acne patients prescribed isotretinoin or antibiotics were more likely to have psychiatric disorders and/or engage in suicidal behavior. Retrospective cohort study identified acne patients prescribed isotretinoin or oral antibiotics in the IBM® MarketScan®. A total of 72,555 patients were included.

Results:
--Compared to acne patients prescribed isotretinoin, patients in the general population were 1.47 times more likely to be diagnosed with suicidal ideation or attempt (adjusted OR 1.47).

--However, the general population (adjusted OR 0.87) and acne patients prescribed antibiotics (adjusted OR 0.88) were less likely to have a psychiatric diagnosis compared to acne patients prescribed isotretinoin.

--The prevalence of suicidal behavior during isotretinoin treatment was lower (0.10%), than during the year prior to (0.22%) and during the year after isotretinoin treatment (0.34%).

Finally, acne patients who were prescribed isotretinoin were less likely to commit suicide than the general population. The small rise in suicidal activity seen in isotretinoin patients one year after therapy warrants further investigation.

Source: https://www.jaad.org/article/S0190-9622(21)00567-3/fulltext?rss=yes
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