Pulmonary Botrytis sp. infection in an apparently healthy in
Botrytis species are well known fungal pathogens of various plants but have not been reported as human pathogens, except as allergenic precipitants of asthma and hypersensitivity pneumonitis.

An asymptomatic patient was referred because of a nodule revealed by chest X-ray. Computed tomography (CT) showed a cavitary nodule in the right upper lobe of the lung. He underwent wedge resection of the nodule, which revealed necrotizing granulomas and a fungus ball containing Y-shaped filamentous fungi, which was confirmed histopathologically. Culture of the specimen yielded white to grayish cotton-like colonies with black sclerotia.

Multilocus gene sequence analyses was performed including three single-copy nuclear DNA genes encoding glyceraldehyde-3-phosphate dehydrogenase, heat-shock protein 60, and DNA-dependent RNA polymerase subunit II. The analyses revealed that the isolate was most similar to Botrytis elliptica. To date, the pulmonary Botrytis sp. infection has not recurred after lung resection and the patient did not require any additional medication.

Source: BMC Infectious Diseases

Read more: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4319-2
Dr. P●●●●●●●●h S●●h
Dr. P●●●●●●●●h S●●h Pathology
Interesting case! Apparently, clinically, and radiologically as well, the case mimics tuberculosis, much can be said about the molecular diagnostic technology, which proved to be a saviour, in addition to the gold standard of sorts(particularly in this case), histopathological examination in this case. Although granulomatous infection in our nation points to the obvious, tuberculosis; confirmatory diagnostic tests must be applied before starting an empirical trial of anti-tuberculosis treatment.... Read more
Aug 6, 2019Like