Pulmonary hypertension tied to adverse acute ischemic stroke
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Pulmonary hypertension was associated with longer hospitalization and lower odds of routine discharge among patients with acute ischemic stroke, researchers reported.

The association between systemic hypertension and cerebrovascular disease is well documented. However, the impact of pulmonary hypertension (PH) on acute ischemic stroke outcomes is unknown despite PH being recognized as a risk factor for acute ischemic stroke. Researchers aimed to determine the association between PH and adverse in-hospital outcomes after acute ischemic stroke, as well as whether there are sex differences in this association.

Acute ischemic stroke admissions from the US National Inpatient Sample between were included. The relationship between PH and outcomes (mortality, prolonged hospitalization more than 4 days, and routine home discharge) was analyzed using logistic regressions adjusting for demographics, comorbidities, and revascularization therapies. Interaction terms between PH and sex and age groups were also included.

A total of 221 249 records representative of 1 106 045 admissions were included; 2.9% of patients had co-morbid PH, and 35.34% of those were male. PH was not associated with in-hospital mortality but was associated with increased odds of prolonged hospitalization and decreased odds of routine discharge for both sexes. Older patients with PH were significantly less likely to be discharged routinely than their younger counterparts. Compared with female patients with PH, men were 31% more likely to die in hospital.

Conclusively, PH was not significantly associated with in-hospital mortality but was associated with prolonged hospitalization and adverse discharge status. Male patients with PH were more likely to die in hospital than female patients.

Source: https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019341
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