Purple fingertips in an elderly woman: how to proceed?
A 72-year-old woman with a history of hypertension and metastatic bladder cancer is referred to the hospital emergency department (ED) by her primary care provider with a complaint of 3 to 4 weeks of gradually worsening bilateral finger pain and cyanosis associated with a 15-lb weight loss. She denies any fever, cold exposure, palpitations, or other complaints.

On examination, the patient is cachectic but appears well hydrated. She has normal vital signs except for her pulse, which is borderline in the 90s. Examination of her head and neck is normal, as is examination of her chest and abdomen. Her extremities have good peripheral pulses, but her fingers are cool and discolored.

Initial concerns include vasculitis, ischemia, infection, emboli, or frostbite. The patient underwent testing in the ED, which revealed the following:
• ECG was normal without ectopy
• Liver function tests and basic metabolic panel were normal
• Complete blood count was normal except for a platelet count of 572,000/µL
• C-rp level and ESR were both extremely elevated

The image depicts what is most likely distal digital ischemia, most consistent with a vasculitic pattern. The next best step would be to conduct more comprehensive laboratory assessment and referral for a hematology/oncology consultation; rheumatology consult may also be considered.

Cryoglobulins, C3 and C4 levels, and coagulation assessment were all normal. Rheumatoid factor was normal; however, antinuclear antibody was >1:640 with a speckled pattern, suggestive of a lupus-like condition. All other lupus antibody tests were normal. The patient was thought to have a paraneoplastic vasculitis. She declined treatment.

This patient's diagnosis, paraneoplastic vasculitis, is a rare vascular complication of malignancy that primarily affects the skin, but this provides a good stimulus to review this and other vascular complications of malignancy outside of the well-known possibilities of deep vein thrombosis/pulmonary embolism and bleeding from vascular invasion.

Read more about the case here: https://pxmd.co/yhfAe
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