Quantitative analysis of gadoxetic acid-enhanced MRI for the
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The quantity of intratumor gadoxetic acid retention could help differentiate focal liver lesions, which is not possible with conventional processing methods, sates a study by the European Journal of Radiology.

The purpose of this study was to compare the estimated quantity of intratumor gadoxetic acid retention using T1 mapping of gadoxetic acid-enhanced magnetic resonance imaging (MRI) versus conventional processing methods for the differential diagnosis of focal liver lesions.

Seventy patients with hepatic lesions (colorectal metastasis (CRM), hepatocellular carcinoma (HCC), hemangioma, and intrahepatic cholangiocarcinoma (ICC)) underwent gadoxetic acid-enhanced MRI, including pre-and post-contrast T1-weighted imaging and T1 mapping.

Quantitative analyses included the lesion-to-liver signal intensity ratio (SIR) on hepatobiliary phase images, the pre-and post-contrast lesion T1 value difference (?T1 [ms]), and the lesion retention index (LRI [%]), which was the estimated intralesional gadoxetic acid retention calculated on pre-and post-contrast T1 maps using a two-compartment pharmacokinetic model.

This study identified significant differences in the LRI of the four lesion subcategories, without significant differences in ?T1 or SIR. The post-hoc analysis demonstrated significant differences in CRM vs. hemangioma, hemangioma vs. ICC, and HCC vs. ICC for the LRI.

Conclusively, the quantity of intratumor gadoxetic acid retention estimated using pre-and post-contrast T1 mapping could distinguish focal liver lesions, unlike conventional processing methods, and captured unique lesion characteristics.

Source: https://doi.org/10.1016/j.ejrad.2021.109620
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