Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mi
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A new study published in The New England Journal of Medicine shows that in people with mild cases of COVID-19, antibodies against SARS-CoV-2 drop sharply over the first three months after infection, decreasing by roughly half every 73 days. If sustained at that rate, the antibodies would disappear within about a year.

• Background
Previous reports have suggested that antibodies against the novel coronavirus are short-lived, but the rate at which they decrease has not been carefully defined. This is the first study to carefully estimate the rate at which the antibodies disappear.

• Method
The researchers studied 20 women and 14 men who recovered from mild cases of COVID-19. Antibody tests were conducted at an average of 36 days and 82 days after the initial symptoms of infection.

• Impact
The findings raise concerns about antibody-based "immunity passports," the potential for herd immunity and the reliability of antibody tests for estimating past infections. In addition, the findings may have implications for the durability of antibody-based vaccines.

Source: https://www.nejm.org/doi/10.1056/NEJMc2025179
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