Rapid gene mutation drives colistin resistance
The hypermutability of one gene in Pseudomonas aeruginosa was shown to drive resistance to colistin, a discovery that researchers said may help improve their understanding of superbugs’ resistan
Colistin is widely regarded as “an important last line of defense” for infections caused by multidrug-resistant (MDR) gram-negative pathogens, and “there is a pressing need to understand how bacterial pathogens adapt to colistin treatment. The bacteria developed resistance “at a much higher rate than expected,” according to the release, but there was hope in the discovery that pathogen populations “quickly lost resistance” once the antibiotic was removed due to the high mutation rate.
Source: https://www.healio.com/news/primary-care/20220623/rapid-gene-mutation-drives-colistin-resistance
Source: https://www.healio.com/news/primary-care/20220623/rapid-gene-mutation-drives-colistin-resistance
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