Rapid transformation of chronic lymphocytic leukemia to acut
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Introduction
CLL is a chronic B-cell lineage lymphoproliferative neoplasm. The incidence of CLL varies worldwide, highest being in North America (7.99/100,000). A majority of the patients of CLL are elderly with median age of 71.5 years and are incidentally diagnosed on routine blood counts. At one extreme CLL follows a long unexciting protracted course with low proliferative activity wherein the patient remains asymptomatic for years, not requiring any treatment or intervention. On the other hand, the disease may be characterized by lymphadenopathy, splenomegaly, anemia, and thrombocytopenia with rapid progression in the clinical and hematological course of the disease.

Over time, patients with CLL may transform into diffuse large B-cell lymphoma, Hogdkin's lymphoma, or B-cell prolymphocytic leukemia (PLL). Few cases of multiple myeloma, hairy cell leukemia may also develop in patients with CLL. However, transformation into acute lymphoblastic leukemia has rarely been reported. In the literature, only a few cases (<1%) of acute leukemic transformation have been reported....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804406/
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