Rate of central corneal thickness changes in primary angle c
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Central corneal thickness (CCT) and its association with intraocular pressure, is a pivotal parameter in glaucoma management. In this study, researchers investigated the long-term change of CCT in terms of rate in eyes with primary angle-closure (PAC) & analyze events that could affect CCT.

A total of 26 patients with PAC with a follow-up time of more than 5 years were studied in this retrospective review. Serial CCT measurements over the average follow-up duration were used to calculate the rate of CCT shifts from baseline. The repeated linear mixed model analysis was used to examine the trend of CCT shift rate in relation to treatment modes and angle-closure attack history.

Results:
--A total of 52 eyes were enrolled.

--The CCT reduction rate of the entire study population was -0.72±0.22 microm/yr with statistical significance.

--The CCT thinning rate of the laser peripheral iridotomy (PI) group was -0.53±0.25 microm/yr and that of the surgical trabeculectomy group was -1.32±0.43 microm/yr, and it was not statistically significant.

--The rate of CCT thinning in patients with a history of acute angle-closure attack was -0.81±0.31 microm/yr and that in patients without an attack was -0.63±0.30 microm/yr, and it was not statistically significant.

--Baseline CCT appeared to be the only significant factor affecting the rate of CCT changes.

In conclusion, PAC eyes showed a substantial reduction in CCT over a long period of time. Different treatment modalities and acute angle-closure attacks had no impact on CCT reduction rates. In the clinical assessment of PAC patients, the study of long-term CCT improvements in combination with baseline CCT will be beneficial.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01908-4
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