Recurrent Bilateral Uveitis Independently Associated with Da
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The treatment of metastatic cutaneous melanoma has traditionally been challenging and often associated with a poor prognosis.However, over the past five years multiple agents have been developed that show promise in successfully treating this aggressive neoplasm. One of these medications, dabrafenib is a reversible adenosine triphosphate-competitive inhibitor that selectively blocks BRAF kinase, resulting in inhibition of the MAPK pathway in melanoma cells. Another novel drug used for treatment of advanced melanoma is pembrolizumab, a monoclonal antibody against the T-cell co-inhibitory receptor programmed death (PD-1) protein.Although ocular effects are uncommon and despite the differences in their mechanism of action, here we report a case of a 61 year old female who developed bilateral uveitis shortly after initiating therapy with dabrafenib and then later developed this same reaction when given pembrolizumab.

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