Recurrent Corneal Perforation due to Chronic Graft versus Ho
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Patients who undergo bone marrow transplantation (BMT) are at risk of developing graft versus host disease (GVHD).GVHD which occurs within the first 100 days of transplantation is termed 'acute' and those developing after 100 days are called 'chronic'. Of patients with chronic GVHD, 60 to 90% have ocular involvement. The most frequent finding in these patients is dry eye (up to 90%). The presence of ocular GVHD has no association with age, gender, or specific conditioning regimens. Chronic GVHD may cause irreparable damage to the cornea including ulceration, thinning and melting.Herein, we describe a case of corneal vascularization and perforation secondary to chronic GVHD and its stepwise management, as well as the results of histopathological evaluation.

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