Recurrent erythema before menses: autoimmune progesterone de
A 35-year-old woman presented with recurrent edematous annular erythema and blisters on the hip (Figure 1) and back, occasionally associated with oral erosions for 6 years. The eruptions appeared 3e5 days before menses and remitted shortly after menstruation (Figure 2). She suffered cervical cancer, ectopic pregnancy, and bilateral salpingectomy at earlyages. Skin biopsy revealed interface dermatitis and necrotic keratinocytes (Figure 3). Intradermal progesterone test induced pruritus within 30 minutes, followed by erythema and swelling (Figure 4), which disappeared the next day.

She was diagnosed with autoimmune progesterone dermatitis and treated with oral contraceptive pills, and the recurrence was partially controlled after 1 cycle. Autoimmune progesterone dermatitis is an autoimmune disorder that occurs exclusively in women of childbearing age. The eruption is a hypersensitivity reaction to the fluctuations of endogenous progesterone during the menstrual cycle.

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