Recurrent pregnancy-induced hemophagocytic lymphohistiocytos
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease primarily of children, characterized by a severe hyperinflammatory state.

Published in the World Journal of Oncology, the authors describe a case of adult-onset familial HLH with a novel exon 19, c.1607G > T (p.Arg536Leu) heterozygous mutation of the UNC13D gene in a 40-year-old woman who developed HLH during her first and second pregnancies, both episodes occurring during the first trimester.

The patient was treated successfully both times with HLH-94 protocol following spontaneous abortions and is currently in the process of getting a bone marrow transplant. The authors also discuss pregnancy as a potential trigger for late-onset familial HLH.

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