Reducing the radioresistance of cancer
Most people recognize that many forms of cancer are treated with radiation therapy. However, some may not realize that there are cancer cells with the ability to survive this type of treatment. Oral squamous cell carcinoma (OSCC) is one of these forms of cancer, and is the reason why researchers from Kumamoto University in Japan began searching for methods to combat resistance to radiotherapy. Rather than going after the cancer cells directly, they attempted to find a way to control the biological mechanisms that aid in radioresistance. This meant looking at interleukin-6 (IL-6), a cytokine known for signaling the inflammatory response, and nuclear factor erythroid 2-related factor 2 (Nrf2), which is a protein that protects against oxidative stress....