Regenerating the Retina
Regenerative therapies hold the promise of restoring vision by replacing diseased retina with normal retina. In recent years, considerable efforts to reprogram stem cells into retinal cells such as photoreceptors have demonstrated the ability to produce photoreceptors and other retinal cell types from embryonic stem cells and induced pluripotent stem cells. However, complete retinal regeneration and integration of these stem cells into injured or diseased retina has not been possible. At Cole Eye Institute, we are using zebrafish to better characterize the injury response of the retina....