Relapse of Exudate in Eyes with Polypoidal Choroidal Vasculo
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A Study was conducted to investigate the association between the inclusion of components identified on images in target spots of photodynamic therapy (PDT) and exudate relapse in eyes with age-related macular degeneration (AMD).

41 eyes with polypoidal choroidal vasculopathy (PCV) and 32 eyes (31 patients) with typical AMD (tAMD) who underwent PDT were retrospectively investigated. Each component identified on fluorescein (FA) or indocyanine angiography (IA), optical coherence tomography (OCT), or color photography was graded as not depicted, covered with a margin more than 500 microm or less than 500 microm, and protruding.

Associations between these grades and the dry rate (proportion of subjects with continuous absence of exudate over following 12-month period) and the relapse index (2 × number of injections administered + accumulation of exudate for 12 months post-PDT) were investigated.

--In PCV, the association between worse coverage and decreasing dry rates for feeder vessels and polyps approached statistical significance.

--With coverage margins more than 500 microm, dry rate tended to be greater than with coverage margins less than 500 microm for feeder vessels, classic lesions, and occult lesions on FA.

--In the tAMD group, coverage with margins more than 500 microm tended to yield a higher dry rate than coverage with margins less than 500 microm for CNV on IA.

--Coverage with margins more than 500 ?m for occult and classic lesions on FA yielded no dry subjects, and all subjects with classic lesions or staining had recurrence.

--Worse coverage and worse dry rate in PCV and worse relapse index in tAMD were related to pigment epithelial detachment on OCT.

Polyps in PCV and pigment epithelial detachment (PED) in tAMD were confirmed as suitable targets, corresponding to existing guidelines, and feeder vessels, classic lesion, occult lesion, and PED in PCV, as well as CNV on IA in tAMD, were suggested as additional targets. For assessing PED, OCT outperformed FA.