Relationship between retinal blood flow and cytokines in cen
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Central retinal vein occlusion (CRVO) is a common condition that often causes macular edema, which is the most frequent reason for visual impairment in these patients. In CRVO, compression of the central retinal vein by an arteriosclerotic central retinal artery in the vicinity of the lamina cribrosa leads to venous thrombosis. Thus, understanding the abnormalities of retinal hemodynamics underlying the pathogenesis of CRVO is critically important.

In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial growth factor (VEGF) therapy. Blood flow was assessed in large vessels around and at the optic disk by determining the mean blur rate using laser speckle flowgraphy. Aqueous humor samples were obtained from the patients during anti-VEGF therapy and levels of the following molecules were measured by the suspension array method.

The mean blur rate of the affected eye was significantly lower than that of the unaffected eye. The mean blur rate showed a significant negative correlation with the log-transformed aqueous humor levels of PlGF, sICAM-1, and IL-8, but not VEGF. These findings suggest that retinal blood flow velocity might be more strongly correlated with inflammatory factors than VEGF in patients with nonischemic CRVO and macular edema.

MBR was significantly lower in the affected eye than the unaffected eye in patients who had nonischemic CRVO and macular edema. MBR showed a significant negative correlation with the log-transformed aqueous humor levels of PlGF, sICAM-1, and IL-8, but not VEGF. Findings suggest that MBR might be better correlated with inflammatory factors such as sICAM-1 than VEGF in patients who have nonischemic CRVO and macular edema.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01486-x
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