Renal-limited “lupus-like” nephritis: how much of a lupus?

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Jul 11, 2017123 views

Lupus nephritis (LN) is a frequent and serious complication in lupus patients. It carries poor prognosis and increased risk of end-stage kidney disease, especially in children. Renal-limited “lupus-like” nephritis is characterized by histopathological findings consistent with LN but without clinical or serological evidence of systemic lupus erythematosus (SLE). The pathogenesis, classification, clinical course, and treatment of renal-limited “lupus-like” nephritis are still unclear. In this article, we present a child with renal-limited “lupus-like” nephritis with no extrarenal manifestations or serological evidence of SLE. We review the literature and highlight some of the possible mechanisms that may explain this condition...

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