Repetitiveness of the oral glucose tolerance test in childre
In mild or moderate disorders of glucose metabolism, such as impaired fasting glucose and impaired glucose tolerance, a diagnosis may not be reached using only one oral glucose tolerance test, and a second test or additional investigations may be needed. When glucose metabolism is profoundly impaired, as, in type 2 diabetes mellitus, one oral glucose tolerance test is probably more reliable and adequate for establishing the diagnosis. Excessive weight and/or a positive family history of type 2 diabetes mellitus possibly affect the insulin and C-peptide response in the oral glucose tolerance test from a young age.

A research was conducted to investigate the usefulness of the oral glucose tolerance test as a screening method for glucose dysregulation in children and adolescents.

Eighty-one children and adolescents, 41 females, either overweight, obese, or normal weight (NW) but with a strong positive family history of type 2 diabetes mellitus (T2DM), were enrolled in the present observational study from the Outpatient Clinic of Paediatric Endocrinology of the University Hospital of Patras in Greece. One or two 3-h oral glucose tolerance tests were performed and glucose, insulin, and C-peptide concentrations were measured at several time points.

Good repetitiveness was observed in the oral glucose tolerance test response with regard to type 2 diabetes mellitus, while low repetitiveness was noted in the oral glucose tolerance test response with regard to impaired glucose tolerance (IGT) and no repetitiveness with regard to impaired fasting glucose (IFG). In addition, no concordance was observed between IFG and impaired glucose tolerance. During the 1st and 2nd oral glucose tolerance tests, no significant difference was found in the glucose concentrations between NW, overweight, and obese patients, whereas insulin and C-peptide concentrations were higher in overweight and obese compared to NW patients at several time points during the oral glucose tolerance tests. Also, overweight and obese patients showed worsening insulin and C-peptide response during the 2nd oral glucose tolerance test as compared to the 1st oral glucose tolerance test.

Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085718/
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