Research finds how brain inflammation may link Alzheimer's r
58 cognitively unimpaired, -amyloid-negative, older adults enriched with parental history of AD (77.6%) and apolipoprotein E (APOE) 4 positivity (25.9%) completed the study. CSF biomarkers of CNS inflammation, -amyloid and tau proteins, and neurodegeneration were combined with polysomnography (PSG) using high-density electroencephalography and assessment of overnight memory retention. Brain inflammation, sleep disturbance and disrupted brain waves have all been associated with Alzheimer's disease. These findings point toward microglia dysfunction as associated with tau phosphorylation, synaptic loss, sleep spindle deficits, and memory impairment even prior to -amyloid positivity, thus offering a promising candidate therapeutic target to arrest cognitive decline associated with aging and AD.