Researchers Develop Non-Invasive Method For Diagnosis Of Cel
Researchers from Spain have developed a non-invasive method that uses saliva for the can help in the diagnosis of celiac disease. The study, has shown that it is possible to considerably reduce the number of endoscopies that are carried out currently via a noninvasive method of diagnosis.

Celiac disease is a complex, autoimmune disorder that affects genetically susceptible individuals. To be able to diagnose celiac disease it is necessary at present to carry out an endoscopy, a test that is highly unpleasant and costly. The genetic variant conferring an increased risk of developing the disease is present in a high percentage of the healthy population. So many non-celiac patients with symptoms and who are at a genetic risk are needlessly subjected to an endoscope.

This was the procedure they followed: firstly, they confirmed that the same inflammation seen in the intestine of celiac patients could be detected in saliva. The inflammation was then quantified in saliva samples from celiac and control patients. These saliva samples were also tested for the genetic risk of developing celiac disease. With these data on inflammation and genetic risk, a predictive formula was developed. The predictive capacity of this model was subjected to a blind test involving 100 saliva samples, and that resulted in a 73% success rate. In addition, the predictive model displayed a sensitivity of 91%, signifying a 91% success rate among people with celiac disease.

Researchers have developed a new way of screening patients with suspected celiac disease before endoscopies are carried out. The method is very useful for screening patients, but it is not 100% accurate and cannot be totally ruled out. Authors propose that only those individuals predicted by this model to have Celiac disease should undergo an endoscopy. This would considerably reduce the number of endoscopes currently performed.

They also showed that the same saliva sample can also be used to test for the genetic risk of the disease, so it could also offer a non-invasive alternative to genetic testing using blood samples, given that the collecting of saliva samples is more convenient than blood collection.

Source:
https://www.sciencedirect.com/science/article/pii/S2352345X21001107
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