Researchers Find Compound That Blocks SARS-CoV-2, Protects L
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Research conducted at Louisiana State University Health New Orleans Neuroscience Center of Excellence reports that 'Elovanoids', bioactive chemical messengers made from omega-3 very long-chain polyunsaturated fatty acids, may block the virus that causes COVID-19 from entering cells and protect the air cells (alveoli) of the lung.

The research team tested Elovanoids (ELVs) on infected lung tissue from a 78-year-old man in petri dish cultures. They found that ELVs not only reduced the ability of the SARS-CoV-2 spike protein to bind to receptors and enter cells, but they also triggered the production of protective, anti-inflammatory proteins that counteract lung damage.

The scientists report that ELVs decreased the production of ACE2. ACE2 is a protein on the surface of many cell types. ACE2 receptors act like locks on cells, and the SARS-CoV-2 spike proteins act like keys that open the locks letting the virus enter cells to multiply rapidly. They also demonstrated for the first time that alveolar cells are endowed with pathways for the biosynthesis of ELVs.

"Since SARS-CoV-2 affects nasal mucosa, the GI tract, the eye, and the nervous system, uncovering the protective potential of ELVs expands the scope of our observations beyond the lung. Our results provide a foundation for interventions to modify disease risk, progression, and protection of the lung from COVID-19 or other pathologies," added Dr Bazan.

Source:
https://www.nature.com/articles/s41598-021-91794-z
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