Researchers identify nanobody that may prevent COVID-19 infe
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells, according to the results published in the journal Nature Communications.

"We hope our findings can contribute to the amelioration of the COVID-19 pandemic by encouraging further examination of this nanobody as a therapeutic candidate against this viral infection," says the corresponding author.

The search for effective nanobodies -- which are fragments of antibodies that occur naturally in camelids and can be adapted for humans -- began in February when an alpaca was injected with the new coronavirus' spike protein, which is used to enter our cells.

After 60 days, blood samples from the alpaca showed a strong immune response against the spike protein.

Next, the researchers cloned, enriched and analysed nanobody sequences from the alpaca's B cells to determine which nanobodies were best suited for further evaluation.

They identified one, Ty1 (named after the alpaca Tyson), that efficiently neutralizes the virus by attaching itself to the part of the spike protein that binds to the receptor ACE2, which is used by SARS-CoV-2 to infect cells. This blocks the virus from slipping into the cells and thus prevents infection.

"Our results show that Ty1 can bind potently to the SARS-CoV-2 spike protein and neutralize the virus, with no detectable off-target activity" says the co-senior author of the publication. "We are now embarking on preclinical animal studies to investigate the neutralizing activity and therapeutic potential of Ty1 in vivo."

Source:https://news.ki.se/researchers-identify-nanobody-that-may-prevent-covid-19-infection?_ga=2.43737189.158112622.1599226000-1932559547.1597712085
Dr. I●●●●●●E G●●●A and 4 others like this3 shares
Like
Comment
Share