Researchers uncover altered brain connectivity after prolong
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Researchers established a prolonged medically induced coma
(pMIC) experimental protocol in mice and found that pMIC alters synaptic brain architecture and object recognition at all ages.

Prolonged medically induced coma (pMIC) is carried out routinely in intensive care medicine. pMIC leads to cognitive impairment, yet the underlying neuromorphological correlates are still unknown.

Investigators establish pMIC (up to 24 h) in adolescent and mature mice, and combine longitudinal two-photon imaging of cortical synapses with repeated behavioral object recognition assessments.

They find that pMIC affects object recognition, and that it is associated with enhanced synaptic turnover, generated by enhanced synapse formation during pMIC, while the postanesthetic period is dominated by synaptic loss.

Conclusively, the result demonstrate major side effects of prolonged anesthesia on neural circuit structure and call for the development of individually tailored anesthetic regimens and intensified research on adjuvant therapeutic strategies to maintain brain structure and function during pMIC.

PNAS
Source: https://doi.org/10.1073/pnas.2023676118
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