Residual Subretinal Fluid Volumes: Impact on Treatment Outco
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In neovascular age-related macular degeneration, researchers investigated the relationships between residual subretinal fluid (rSRF) volumes quantified using artificial intelligence (AI) and patient results in an SRF-tolerant treat-and-extend (T&E) protocol (nAMD).

Patients randomized in an SRF-tolerant T&E protocol in the prospective, multicenter FLUID sample were examined with SD-OCT and screened for BCVA. AI-tools were used to calculate the volumes of the SRF and intraretinal fluid (IRF). Extended intervals despite rSRF and extended intervals without fluid were split into two subgroups from 375 visits from 98 patients. Linear mixed models were used to estimate associations between BCVA transition, SRF volume, subgroups, and treatment intervals.

Results:
--In extended intervals despite rSRF, increased SRF was associated with reduced BCVA at the next visit in the central 1mm (-0.138 letters/nl) and 6mm (-0.024 letters/nl).

--A negative association between increased interval and BCVA change was found for rSRF in 1 and 6mm (-0.250 and -0.233 letter/week interval, respectively).

--Extended intervals despite rSRF had significantly higher SRF-volumes in the central 6mm at the following visit.

Finally, AI-based study of extended visits amid rSRF revealed an association between increasing SRF-volumes and BCVA loss at the subsequent visit. This negative correlation adds to knowledge the impact of rSRF volumes on nAMD treatment outcomes.

Source: https://journals.lww.com/retinajournal/Abstract/9000/Impact_of_Residual_Subretinal_Fluid_Volumes_on.95522.aspx
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