Respiratory Syncytial Virus-Associated Neurologic Complicati
A Study was conducted to describe the features and frequency of RSV-associated severe acute neurologic disease in children.

A systematic review was performed to identify reports of severe acute neurologic complications associated with acute respiratory syncytial virus (RSV) infection in children aged less than 15 years. Main outcomes included neurologic, clinical, and demographic features of cases, and the frequency of disease.

--87 unique studies from 26 countries were identified describing a spectrum of RSV-associated severe acute neurologic syndromes including proven encephalitis, acute encephalopathy, complex seizures, hyponatremic seizures, and immune-mediated disorders.

--The frequency of RSV infection in acute childhood encephalitis/encephalopathy was 1.2 to 6.5%.

--Data from 155 individual cases were checked with RSV-associated severe acute neurologic complications; median age was 11.0 months (IQR 2.0-21.5), most were previously healthy (71/104, 68%).

--Seizure was the most frequently reported neurologic feature. RSV was detected in the central nervous system of 12 cases. Most children recovered, however some reports described partial recovery and death.

In conclusion, neurological problems related with RSV have been widely described, however the design and quality of available research are significantly heterogeneous. The study findings have significance for the study, management and prevention of neurological problems linked with RSV.